Selection of Diagnostic and Therapeutic Articles

List of diagnostic articles:

1.  Soluble f-Amyloid Induction of Alzheimer's Phenotype for Human Fibroblast K+ Channels    Science - Rene Etcheberrigaray, Etsuro Ito, Christopher S. Kim, Daniel L. Alkon – 1994

2.  An internally controlled peripheral biomarker for Alzheimer’s disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin  PNAS - Tapan Khan and Daniel L. Alkon – 2006

3.  A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts Neurobiology of Disease - Tapan K. Khan, Thomas J. Nelson, Vishal A. Verma, Paul A. Wender, Daniel L. Alkon – 2009

4.  Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer’s disease peripheral biomarker Neurobiology of Aging - Tapan Khan and Daniel Alkon – 2010

5.  Spatiotemporal Complexity of Fibroblast Networks Screens for Alzheimer’s Disease Journal of Alzheimer's Disease - Florin Chirila, Tapan Khan, Daniel Alkon – 2013

6.  Fibroblast Aggregation Rate Converges with Validated Peripheral Biomarkers for Alzheimer’s Disease Journal of Alzheimer's Disease - Florin Chirila, Tapan Khan, Daniel Alkon – 2014

7.  Journal of Alzheimer's Disease - Florin Chirila, Tapan Khan, Daniel Alkon – 2014

8.  Peripheral Biomarkers of Alzheimer’s Disease Journal of Alzheimer's Disease - Tapan Khan, Daniel Alkon – 2015

9. Alzheimer’s Disease Cerebrospinal Fluid and Neuroimaging Biomarkers: Diagnostic Accuracy and Relationship to Drug Efficacy Journal of Alzheimer’s Disease - Tapan Khan, Daniel Alkon – 2015

List of therapeutic articles:

1.  PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer’s disease Trends in Pharmacological Sciences - Daniel L. Alkon, Miao-Kun Sun and Thomas J. Nelson – 2007

2.  A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC PNAS - Jarin Hongpaisan and Daniel L. Alkon – 2007

3.  Neuroprotective versus tumorigenic protein kinase C activators Trends in Biochemical Sciences - T.J. Nelson and D.L. Alkon – 2008

4.  PKC Activation Prevents Synaptic Loss, A Elevation, and Cognitive Deficits in Alzheimer’s Disease Transgenic MiceNeurobiology of Disease - Jarin Hongpaisan, Miao-Kun Sun, and Daniel L. Alkon – 2011

5.  Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase C The Journal of Biological Chemistry - Abhik Sen, Daniel L. Alkon, and Thomas J. Nelson - 2012

6.  Towards universal therapeutics for memory disorders Trends in Pharmacological Sciences - Miao-Kun Sun, Thomas J. Nelson, and Daniel L. Alkon – 2015

7.  ApoE4 and A Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation The Journal of Neuroscience - Abhik Sen, Daniel L. Alkon, and Thomas J. Nelson - 2015

8.  Protein Kinase C (PKC) Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95 The Journal of Neuroscience - Abhik Sen, Daniel L. Alkon, and Thomas J. Nelson - 2016

9.  A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer’s Disease Journal of Alzheimer’s Disease - Martin R. Farlow, Richard E. Thompson, Lee-Jen Wei, Alan J. Tuchmand, Elaine Greniere,David Crockforde, Susanne Wilkee, Jeffrey Benison and Daniel L. Alkon - 2018

10.  Neuro-regeneration Therapeutic for Alzheimer’s Dementia: Perspectives on Neurotrophic Activity  Trends in Pharmacological Sciences - Miao-Kun Sun, and Daniel L. Alkon – 2019